Lasmiditan Catalog No.:M10338-10 Chemical Name: (R)-3-(2

Chemical Name: (R)-3-(2

Dihexa has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment

5)6)15-17-30(16-14-28)20-23(33)36-26(7

Smiles: CC1(C)[C@@H]2[C@@H](O)C[C@]3(C)[C@H](C[C@@H](O)[C@@H]4[C@H](CC[C@@]34C)[C@@](C)(O)CCC=C(C)C)[C@@]2(C)CC[C@@H]1O

116(7):937-943

Lasmiditan Catalog No.:M10338-10 Chemical Name: (R)-3-(2Lasmiditan, also known as COL 144 and LY573144, is a novel, centrally acting, highly selective 5 HT(1F) receptor agonist (K1=2. 21 M) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof of concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2 hour placebo subtracted headache response of 28. 8%, though with frequent reports of dizziness, paresthesias, and vertigo.