LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 PubMed Central PMCID: PMC3754927

PubMed Central PMCID: PMC3754927

MERcK-5 reduces IFN-γ and IL-13

it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status

Angew Chem Int Ed Engl

It was also used in an assay where primary bovine articular chondrocytes and cartilage explants were grown in the presence of TNF-a and oncostatin M to mimic cytokine-induced damage during OA pathogenesis

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 PubMed Central PMCID: PMC3754927LY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is