ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 LSB CI994 was administered to mice

CI994 was administered to mice via oral gavage (PO) or intraperitoneal injection (IP) at 5-35 mg/kg once per day

HLY78 as a specific Wnt synergistic activator presents another opportunity for potential clinical applications relevant to the Wnt pathway

DMOG was used at 100 µM final concentration in vitro and in cellular assays

Formula: C22H12Cl4N2O4

2013 Oct 22

ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 LSB CI994 was administered to miceISRIB (trans isomer), CAS No. 1597403 47 8, is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2 phosphorylation (IC50=5 nM). In cells, distinct stress conditions activate different downstream kinases, including PERK, that converge on phosphorylating the subunit of initiation factor 2 (eIF2 ). This collection of signaling pathways is termed the integrated stress response (ISR). Trans ISRIB is a potent and