TTR mouse Monoclonal Antibody(5D2), 100ul Immune Repertoire Sequencing This proto-oncogene

This proto-oncogene

POM121 (POM121 transmembrane nucleoporin) encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex

Three subunits (alpha| beta and gamma) of the 11S regulator have been identified

The surface expression of these ligands is important for the recognition of stressed cells by the immune system

Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor

TTR mouse Monoclonal Antibody(5D2), 100ul Immune Repertoire Sequencing This proto-oncogeneThis gene encodes transthyretin, one of the three prealbumins including alpha 1 antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported most mutations are related to amyloid