SH3K1 Polyclonal Antibody, 50ul Pipette Filler There are pseudogenes for this

There are pseudogenes for this gene on chromosomes 1 and 15

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2

Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activition or by arresting cell growth in G1 phase in a p53-dependent manner

is ubiquitously expressed and localized in the cytoplasm

Two transcript variants resulting from alternative splicing of the 3' terminal exon

SH3K1 Polyclonal Antibody, 50ul Pipette Filler There are pseudogenes for thisThis gene encodes an adapter protein that contains three N terminal Src homology domains, a proline rich region and a C terminal coiled coil domain. The encoded protein facilitates protein protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin dependent endocytosis. Alternate splicing results in multiple transcript variants.