ERLN2 Rabbit Polyclonal Antibody, 50ul Protein Expression Interacts with the phosphorylated carboxyterminal

Interacts with the phosphorylated carboxyterminal domain of POLR2A

It is involved in mammalian pigmentation

and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death

and negatively regulates the mTOR kinase

There is evidence for multiple polyadenylated sites for this transcript

ERLN2 Rabbit Polyclonal Antibody, 50ul Protein Expression Interacts with the phosphorylated carboxyterminalThis gene encodes a member of the SPFH domain containing family of lipid raft associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1 4 5 trisphosphate (IP3) signaling by mediating ER associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia 18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms