SIR4 Polyclonal Antibody, 100ul Nucleic Acid Amplification These proteins are basic helix-loop-helix

These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity

Heterozygous loss-of-function mutations in KLF1 result in the dominant In (Lu) blood phenotype

The protein associates with hamartin in a cytosolic complex

The suspended design positions the etched membrane approximately 1

Polymorphisms in this gene have been linked to Alzheimer's disease in some populations

SIR4 Polyclonal Antibody, 100ul Nucleic Acid Amplification These proteins are basic helix-loop-helixThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular