GMIP Rabbit Polyclonal Antibody, 50ul Endonucleases & Exonucleases Spastic paraplegias are a diverse

Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive| lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts

This gene encodes a member of the acyl-coenzyme A binding domain containing protein family

653 bases and maps to human chromosome 2q14

P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes

and at lower levels on dendritic cells and natural killer cells

GMIP Rabbit Polyclonal Antibody, 50ul Endonucleases & Exonucleases Spastic paraplegias are a diverseThis gene encodes a member of the ARHGAP family of Rho Rac Cdc42 like GTPase activating proteins. The encoded protein interacts with the Ras related protein Gem through its N terminal domain. Separately it interacts with RhoA through a RhoGAP domain and stimulates RhoA dependent GTPase activity. Alternative splicing results in multiple transcript variants.