CLN3 Polyclonal Antibody, 20ul Stepper ARVCF contains a predicted nuclear-targeting

ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein

Mutations in PMS1 cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype

When the function of this gene is lost

Contains 5 C2HC-type zinc fingers

It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid

CLN3 Polyclonal Antibody, 20ul Stepper ARVCF contains a predicted nuclear-targetingThis gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.