TPH2 Polyclonal Antibody, 100ul Peptide Modification tumor suppressor mediated growth arrest

tumor suppressor mediated growth arrest and replicative senescence

This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers

A 117 kb microdeletion at the 5' end of the HOXD gene cluster| which includes this gene and the HOXD9-HOXD13 genes| causes synpolydactyly| a dominantly inherited disease resulting in limb malformation

The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein

telomere maintenance

TPH2 Polyclonal Antibody, 100ul Peptide Modification tumor suppressor mediated growth arrestTPH2 encodes a member of the pterin dependent aromatic acid hydroxylase family. The tryptophan hydroxylase 2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.