TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Imprinting defects at chromosome 11p13

Imprinting defects at chromosome 11p13 may contribute to tumorigenesis

Charcot-Marie-Tooth disease

this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas

The receptor functions as a neurotransmitter-gated ion channel

growth control

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Imprinting defects at chromosome 11p13Catalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only