Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter but their full-length natures have

but their full-length natures have not been determined

Multiple alternatively spliced variants

Involved in protein trafficking

CHRNA1 encodes an alpha subunit that plays a role in acetlycholine binding/channel gating

A pseudogene COX17P has been found on chromosome 13

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter but their full-length natures haveMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.