MARCH2 Polyclonal Antibody, 50ul Glassware lacking the N-terminal hydrophobic region

lacking the N-terminal hydrophobic region but retaining the same activity

Several alternatively spliced transcript variants encoding different isoforms have been described for MED23

This gene is expressed in kidney and brain

suggesting diverse functions in signal transduction

It is a human homolog of the E

MARCH2 Polyclonal Antibody, 50ul Glassware lacking the N-terminal hydrophobic regionMARCH2 (membrane associated ring CH type finger 2) is a member of the MARCH family of membrane bound E3 ubiquitin ligases. MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome to trans Golgi network (TGN) trafficking.