PTEN(Phospho Ser370) Polyclonal Antibody, 20ul Serological Pipets Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants have been reported for this gene

DEFA3 differs from defensin

Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia

The interaction of this PTP with BMX kinase was found to increase the activation of STAT3

an hydrophobic stretch corresponding to a single pass transmembrane region

PTEN(Phospho Ser370) Polyclonal Antibody, 20ul Serological Pipets Multiple alternatively spliced transcript variantsThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide