HES1 Polyclonal Antibody, 100ul General Lab Use Chromosomal translocations involving CREBBP have

Chromosomal translocations involving CREBBP have been associated with acute myeloid leukemia

Mutations in TSC1 have been associated with tuberous sclerosis

SF3B3 encodes subunit 3 of the splicing factor 3b protein complex

where heterozygotes carrying an active paternal allele express the phenotype

This protein localizes to cytoplasmic filaments

HES1 Polyclonal Antibody, 100ul General Lab Use Chromosomal translocations involving CREBBP haveThis protein belongs to the basic helix loop helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N box rather than the canonical E box.