KPCD3 Polyclonal Antibody, 100ul Drug Development and Evaluation The protein encoded by LAT

The protein encoded by LAT (linker for activation of T-cells) is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway

The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site| and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton| possibly by direct association with actin or spectrin

PcG PRC1 complex acts via chromatin remodeling and modification of histones

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex

Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL

KPCD3 Polyclonal Antibody, 100ul Drug Development and Evaluation The protein encoded by LATThis gene belongs to the multigene protein kinase D family of serine threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N terminal regulatory domain comprised of a tandem repeat of cysteine rich zinc finger motifs and a pleckstrin domain. The C terminal region contains the catalytic domain and is distantly related to calcium regulated kinases. Catalytic activity of this enzyme promotes its