Raf-1 Polyclonal Antibody, 20ul[BT-AP13537] Yeast Expression Alternatively spliced variants

Alternatively spliced variants

Mutations in BTK cause X-linked agammaglobulinemia type 1

MBP-related transcripts are also present in the bone marrow and the immune system

suggesting a link with Alzheimer disease

Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized

Raf-1 Polyclonal Antibody, 20ul[BT-AP13537] Yeast Expression Alternatively spliced variantsThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.