Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing This gene contains at least

This gene contains at least 14 exons| and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons

it is now thought to be a non-opioid receptor

This protein mediates the signals of the bone morphogenetic proteins (BMPs)| which are involved in a range of biological activities including cell growth| apoptosis| morphogenesis| development and immune responses

The protein may also be involved in the pathophysiology of depression

Mutations in this gene are associated with generalized glucocorticoid resistance

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing This gene contains at leastThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.