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NUMB Polyclonal Antibody, 50ul Drug Development and Evaluation although its function has not

SKU: 288024852

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NUMB Polyclonal Antibody, 50ul Drug Development and Evaluation although its function has notProtein numb homolog encoded by NUMB plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome dependent manner by MDM2, is a membrane bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants.

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Description

although its function has not been well established

with homology to gp130

is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage

a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators

The protein encoded by this gene interacts with several other proteins

NUMB Polyclonal Antibody, 50ul Drug Development and Evaluation although its function has notProtein numb homolog encoded by NUMB plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome dependent manner by MDM2, is a membrane bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants.

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