p53 Polyclonal Antibody, 50ul[BT-AP06832] Molecular Sciences Loeys-Deitz Aortic Aneurysm Syndrome

Loeys-Deitz Aortic Aneurysm Syndrome

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes

The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM

Mutations in this gene are associated with erythrocytosis familial type 4

which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus

p53 Polyclonal Antibody, 50ul[BT-AP06832] Molecular Sciences Loeys-Deitz Aortic Aneurysm SyndromeTP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni