CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction This gene encodes a nuclear

This gene encodes a nuclear protein involved in homologous recombination

also known as family 2 of ubiquitin carboxyl-terminal hydrolases

MIM 604766)

Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778

The CARD domains of both proteins have been shown to specifically interact with BCL10| a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation

CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction This gene encodes a nuclear