IMP-3 Monoclonal Antibody, 100ul Monoclonal Antibodies This protein binds to the

This protein binds to the SH3 domains of GRB2| an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras)| via its C-terminal proline-rich sequences| and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2

A related protein in mouse suggests that this protein (armadillo repeat containing 6) has a conserved function

The product of this gene functions in the nucleotide excision repair pathway

Guanine nucleotide exchange factor (GEF) for Rap1A

and may play a role in regulating the apoptotic events in the dying cell

IMP-3 Monoclonal Antibody, 100ul Monoclonal Antibodies This protein binds to theThe protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin like growth factor II leader 3 mRNA and may repress translation of insulin like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative