IKK alpha/beta(Phospho Ser176/177) Polyclonal Antibody, 100ul Endonucleases & Exonucleases Members of this family participate

Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation

This gene may show increased expression in the adrenal gland and lymphatic tissues

and pharmacologic properties

Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis

Alternative splicing has been observed for this locus and two variants are described

IKK alpha/beta(Phospho Ser176/177) Polyclonal Antibody, 100ul Endonucleases & Exonucleases Members of this family participateThis gene encodes a member of the serine threonine protein kinase family. The encoded protein a component of a cytokine activated protein complex that is an inhibitor of the essential transcription factor NF kappa B complex phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway thereby activating the transcription factor.