Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing Plays an essential role in

Plays an essential role in autophagy

suppressed by proinflammatory mediators like lipopolysaccharide (LPS)| Interferon gamma/IFNG| and tumor necrosis factor alpha

This gene is a member of the metallocarboxypeptidase gene family

including those that encode for chemokines

Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms

Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing Plays an essential role inThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF beta receptor type 1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding